While combining melatonin and tylenol may enhance pain relief, it's essential to be mindful of their individual side effects and drug interactions. Both melatonin and tylenol can cause drowsiness, so combining them may intensify this effect. Tylenol pm (acetaminophen / diphenhydramine) and melatonin using diphenhydramine together with melatonin may increase side effects such as dizziness,.
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